Investigator at GSK in Collegeville, PA

NMR spectroscopist - Investigator

GSK has an immediate opening for an NMR spectroscopist in research and development at our site in Collegeville, PA.

The NMR team is accountable for all NMR applications in support of drug discovery and development from lead identification to marketing authorization applications. This includes structural characterization of new chemical entities, synthetic intermediates, impurities, and degradants, characterization of physical form with solid state NMR, as well as development of NMR methodology for novel applications. The NMR team maintains seven NMR instruments ranging from 400 MHz to 700 MHz including solid state NMR capability, and also five additional walk-up NMR’s for use within Medicinal Chemistry and Process Chemistry groups.

The NMR team sits within a broader, multi-disciplinary analytical group responsible for structural characterization of small molecule synthetic drugs and biologics such as monoclonal antibodies by mass spectrometry, spectroscopy, and other biophysical techniques as well as stress testing/forced degradation studies. Our group supports the development of innovative and quality medicines for patients through cutting-edge analytical science.

Basic Qualifications

PhD in NMR spectroscopy or related area (or Masters degree with equivalent experience)
Experience with both solution and solid state NMR experiments, including ability to apply 1D, 2D, and heteronuclear NMR techniques for structural characterization of analytes.
Experience with NMR instrumentation hardware and software, including solid state NMR and low field / benchtop NMR systems
Experience in solving challenging problems in NMR
Experience building and maintaining a state-of-the-art NMR laboratory
Demonstrated ability to contribute to authoring of reports and regulatory dossiers
Ability to comply with the requirements of Quality, Safety and GSK policies and procedures and ensure that GSK intellectual property is protected

Preferred qualifications

≥ 5 years’ experience in the field (or a Masters degree with ≥ 10 years)
Demonstrated expertise in modern NMR pulse sequence programming and AU/macro programming on Bruker spectrometers. Experience in structure elucidation software (e.g. ACD) for NMR
Working knowledge of low field (benchtop) NMR applications and methodology development
Expertise in automated sample preparation, acquisition, and data analysis
Knowledge of closely related scientific disciplines as they apply to drug discovery and development (e.g. mass spectrometry, vibrational spectroscopy, XRPD, any other techniques) and ability to engage in cross-disciplinary teams
Demonstrated ability to integrate scientific data and spectroscopic/spectrometric techniques other than NMR help determine the structure of analytes
Excellent communication skills and teamwork behaviors
Experience with the overall drug development process, including GxP requirements.
Demonstrated knowledge and application of Digital, Data and Analytics principles, tools, and approaches

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture.

These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
Continuously looking for opportunities to learn, build skills and share learning.
Sustaining energy and well-being
Building strong relationships and collaboration, honest and open conversations.
Budgeting and cost-consciousness

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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